Cortisol, often called the "stress hormone," is essential for survival—it’s what kicks in when you need to react quickly, like slamming on the brakes in traffic. But when cortisol stays elevated over time, it can start wreaking havoc on your health. Chronic high cortisol can lead to anxiety, weight gain, sleep issues, and even chronic disease. While managing stress through lifestyle changes like diet, exercise, and sleep is key, some supplements can offer extra support. Here’s a rundown of science-backed supplements that actually help keep cortisol in check.

1. Ashwagandha: The Adaptogenic Powerhouse

What It Is:
Ashwagandha is a powerful adaptogenic herb that’s been used in traditional Ayurvedic medicine for centuries. Adaptogens are natural substances that help the body adapt to stress and bring systems back into balance.

How It Works:
Ashwagandha is particularly well-researched for its cortisol-lowering effects. In one randomized controlled trial, participants who took 250 mg or 600 mg of Ashwagandha daily saw significant reductions in cortisol levels.

The Science:
Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study on the safety and efficacy of Ashwagandha root for reducing stress. Indian Journal of Psychological Medicine, 34(3), 255-262.

2. Fish Oil: Omega-3 Fatty Acids for Stress

What It Is:
Fish oil is rich in omega-3 fatty acids, particularly EPA and DHA—two essential fats that play key roles in brain health and inflammation management.

How It Works:
Omega-3 fatty acids have been shown to reduce cortisol and improve stress resilience. One study involving over 2,700 participants found that higher omega-3 levels in the blood were linked to lower cortisol levels and reduced inflammation.

The Science:
Delarue, J., et al. (2003). Fish oil prevents adrenal activation under mental stress. Diabetes & Metabolism, 29(3), 289-295.

3. Phosphatidylserine: Brain Booster and Stress Reducer

What It Is:
Phosphatidylserine is a phospholipid found in high concentrations in the brain. It’s essential for cognitive function and helps maintain healthy cell membranes in the nervous system.

How It Works:
Phosphatidylserine has been shown to reduce cortisol, especially after exercise-induced stress. It’s also studied for improving mood and reducing anxiety, making it a powerful supplement for anyone dealing with chronic stress.

The Science:
Monteleone, P., et al. (1990). Effects of phosphatidylserine on neuroendocrine responses to stress. Neuroendocrinology, 52(3), 243-248.

4. L-Theanine: Calm in a Capsule

What It Is:
L-Theanine is an amino acid found primarily in green tea, known for promoting relaxation without causing drowsiness.

How It Works:
L-Theanine has a calming effect on the brain by increasing the production of neurotransmitters like GABA, serotonin, and dopamine. These work together to reduce stress and cortisol, helping you stay calm and focused.

The Science:
Kimura, K., et al. (2007). L-Theanine reduces psychological and physiological stress responses. Biological Psychology, 74(1), 39-45.

5. Magnesium: The Anti-Stress Mineral

What It Is:
Magnesium is a vital mineral involved in over 300 biochemical reactions, including those that regulate nerve function, blood sugar, and blood pressure.

How It Works:
Often called the "relaxation mineral," magnesium helps calm the nervous system and lower cortisol, particularly in people under chronic stress. Magnesium also improves sleep, which is crucial for managing cortisol.

The Science:
Tarleton, E. K., & Littenberg, B. (2015). Magnesium intake and depression correlation. Journal of the American Board of Family Medicine, 28(2), 249-256.

6. Rhodiola Rosea: The Energy Balancer

What It Is:
Rhodiola Rosea is an adaptogenic herb that helps the body resist the effects of stress and fatigue.

How It Works:
Rhodiola has been shown to reduce cortisol and improve symptoms of stress and burnout. It works by balancing the body’s stress-response system and increasing mental performance under pressure.

The Science:
Spasov, A. A., et al. (2000). Rhodiola Rosea SHR-5 extract effects on stress-induced fatigue. Phytomedicine, 7(2), 85-89.

7. Vitamin C: Immune Support and Stress Reduction

What It Is:
Vitamin C is a powerful antioxidant essential for immune health, skin repair, and adrenal gland function.

How It Works:
High doses of Vitamin C can reduce cortisol, particularly in response to acute stress. It supports adrenal function and reduces oxidative stress, which is often elevated in people with high cortisol levels.

The Science:
Brody, S., et al. (2002). High-dose vitamin C effects on stress response. Psychopharmacology, 166(3), 174-180.

Final Thoughts: Choosing the Right Supplements for Cortisol Management

While supplements can provide valuable support for managing cortisol, they’re not a magic cure. They work best when paired with lifestyle strategies—like regular exercise, sleep, and mindfulness practices—that also help lower cortisol. If you’re dealing with chronic stress, adding one or more of these science-backed supplements could help you feel more balanced and resilient.

But remember: always consult a healthcare provider before starting any new supplement, especially if you’re on medication or have an existing health condition. That way, you can ensure the supplement is right for you and won’t interfere with anything else you’re taking.

Here’s to balanced cortisol and a more stress-free life!

Other articles you MIGHT be interested in…